| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[8] Antibiotics, oral (AOM-children): Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2015 Jun 23;(6):CD000219. https://www.ncbi.nlm.nih.gov/pubmed/26099233
Antibiotics, oral (AOM-children): NICE. Otitis media (acute): antimicrobial prescribing. Clinical guideline NG91, March 2018. https://www.nice.org.uk/guidance/ng91