| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[23] Corticosteroids (fatigue): Mücke M; Mochamat, Cuhls H, Peuckmann-Post V, Minton O, Stone P, Radbruch L. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev. 2015 May 30;(5):CD006788. https://www.ncbi.nlm.nih.gov/pubmed/26026155
Corticosteroids (fatigue): National Department of Health: Affordable Medicines, EDP-Primary Health Care. Medicine Review: Betamethasone/dexamethasone for management of fatigue in adult palliative care patients, 29 July 2017. http://www.health.gov.za/
Corticosteroids (fatigue): Radbruch L, Strasser F, Elsner F, Gonçalves JF, Løge J, Kaasa S, Nauck F, Stone P; Research Steering Committee of the European Association for Palliative Care (EAPC). Fatigue in palliative care patients -- an EAPC approach. Palliat Med. 2008 Jan;22(1):13-32. https://www.ncbi.nlm.nih.gov/pubmed/18216074