| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[5] Proton pump inhibitor, oral: Sigterman KE, van Pinxteren B, Bonis PA, Lau J, Numans ME. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Cochrane Database Syst Rev. 2013 May 31;5:CD002095. http://www.ncbi.nlm.nih.gov/pubmed/23728637
Proton pump inhibitor, oral (therapeutic class): National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Medicine Review: PPIs, therapeutic class review, April, 2018. http://www.health.gov.za/